Signal Joint T-Cell Receptor Excision Circle Assay in Miniature Swine
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منابع مشابه
A Practical Approach to Newborn Screening for Severe Combined Immunodeficiency Using the T Cell Receptor Excision Circle Assay
Severe combined immunodeficiency (SCID) is a life-threatening condition of newborns and infants caused by defects in genes involved in T cell development. Newborn screening (NBS) for SCID using the T cell receptor excision circle (TREC) assay began in Wisconsin in 2008 and has been adopted or is being implemented by all states in 2017. It has been established that NBS using the TREC assay is ex...
متن کاملT-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events.
It is generally believed that homeostatic responses regulate T-cell recovery after peripheral stem cell transplantation (PSCT). We studied in detail immune recovery in relation to T-cell depletion and clinical events in a group of adult patients who underwent PSCT because of hematologic malignancies. Initially, significantly increased proportions of dividing naive, memory, and effector CD4(+) a...
متن کاملTwo Subsets of Naive T Helper Cells with Distinct T Cell Receptor Excision Circle Content in Human Adult Peripheral Blood
During ageing thymic function declines and is unable to meet the demand for peripheral T helper (Th) cell replenishment. Therefore, population maintenance of naive Th cells must be at least partly peripherally based. Such peripheral postthymic expansion of recent thymic emigrants (RTEs) during ageing consequently should lead to loss or dilution of T cell receptor excision circles (TRECs) from a...
متن کاملT Cell Receptor Excision Circle (TREC) Monitoring after Allogeneic Stem Cell Transplantation; a Predictive Marker for Complications and Clinical Outcome
Allogeneic hematopoietic stem cell transplantation (HSCT) is a well-established treatment modality for a variety of malignant diseases as well as for inborn errors of the metabolism or immune system. Regardless of disease origin, good clinical effects are dependent on proper immune reconstitution. T cells are responsible for both the beneficial graft-versus-leukemia (GVL) effect against maligna...
متن کاملHigh Throughput Newborn Screening for Severe Combined Immunodeficiency (SCID) Using the Automated T-cell Receptor Excision Circle (TREC) in situ Assay
High Throughput Newborn Screening for Severe Combined Immunodeficiency (SCID) Using the Automated T-cell Receptor Excision Circle (TREC) in situ Assay R. Haughton, S. Dever, K. Turner, L. Hancock, J. Taylor, Golriz Yazdanpanah, F. Lee; Virginia Division of Consolidated Laboratory Services, Richmond, VA, Centers for Disease Control and Prevention, Atlanta, GA, RTI International, Research Triangl...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2011
ISSN: 0041-1337
DOI: 10.1097/tp.0b013e31822b9287